It was studied simulated acrylic fiber wastewater treatment used membrane bioreactor. In Lab research, the fouling mechanisms of the membrane in microfihration were studied. Every kind of resistances in the simulated acrylic fiber wastewater treatment was analyzed. The results show that the fouling is mainly from concentration polarization and cake layer under the conditions of the lower operating pressure. However, the fouling mainly from cake layer under the conditions of the higher operating pressure. The resistances from the block and itself is small, thus, they are the minor factors for the membrane fouling. The method of membrane cleaning were proposed, that is, membrane flux is up to better level after 1% H
2O
2 solution washing for 30 min or 0.1 mol/ L NaOH solution washing for 60 min.